R. Rabadan

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

This study uses scRNA-seq data from mouse and human prostate tissues to show epithelial plasticity in regression, regeneration, and cancer, with findings on cell type origins and AR signaling heterogeneity.

Cytotoxic chemotherapy potentiates the immune response and efficacy of combination CXCR4/PD-1 inhibition in models of pancreatic ductal adenocarcinoma

This study shows that combining gemcitabine with CXCR4 inhibitors and anti-PD1 therapy improves immune response and survival in pancreatic cancer models.

Computational structure prediction methods enable the systematic identification of oncogenic mutations

This paper introduces a computational method to identify oncogenic mutations by integrating evolutionary information and protein structure prediction, demonstrating its effectiveness in pediatric leukemias.

Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma (DMG)

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma

This study shows that radiation therapy promotes unsaturated fatty acid accumulation in glioblastoma, enhancing survival by reducing ER stress, and that targeting lipid metabolism could improve treatment outcomes.

Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas

This study identifies cell-surface markers to isolate distinct cell types in ACC, shows myoepithelial-like cells as progenitors of ductal-like cells, and demonstrates RA signaling modulation as a therapeutic strategy.

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

This study identifies SF3B1 mutations causing anemia in MDS by inducing missplicing of MAP3K7, leading to reduced p38 MAPK activity and disrupted erythroid differentiation.

Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2

This paper identifies an ancestral recombination event in the RBD of SARS-CoV and SARS-CoV-2 that increased hACE2 binding affinity, suggesting SARS-like viruses may have pandemic potential.

Identification of Relevant Genetic Alterations in Cancer using Topological Data Analysis

This study identifies 38 candidate cancer-associated genes using topological data analysis integrated with somatic mutations and RNA expression data across 12 tumor types.

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.