L. Aparicio

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

This study uses scRNA-seq data from mouse and human prostate tissues to show epithelial plasticity in regression, regeneration, and cancer, with findings on cell type origins and AR signaling heterogeneity.

Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas

This study identifies cell-surface markers to isolate distinct cell types in ACC, shows myoepithelial-like cells as progenitors of ductal-like cells, and demonstrates RA signaling modulation as a therapeutic strategy.