Author

P. Darcy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. K. Dhara· 1 shared C. Xirouchaki· 1 shared F. Wiede· 1 shared H. K. Patra· 1 shared J. Hinkula· 1 shared K. Roberg· 1 shared K. Sek· 1 shared K.-H. Lu· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. K. Dhara

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2 papers

Recent·Most cited

PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

F. Wiede, K.-H. Lu, X. Du, M. Zessig, R. Xu, P. K. Goh, C. Xirouchaki, S. Hogarth, S. Greatorex, K. Sek, R. Daly, P. Beavis, P. Darcy, N. Tonks, T. Tiganis

This study identifies PTP1B as an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity, showing its deletion or inhibition enhances tumor suppression.

bioRxiv · Nov 11, 2021Cancer Biology

Multicellular tumor spheroids- an effective in vitro model for understanding drug resistance in head and neck cancer

M. Azharuddin, K. Roberg, A. K. Dhara, M. V. Jain, P. Darcy, J. Hinkula, N. K. H. Slater, H. K. Patra

This paper develops an integrated approach using multicellular tumor spheroids to differentiate between multi-drug resistant and non-resistant cancer cells in head and neck cancer.

bioRxiv · Jul 24, 2019 · PreprintCancer Biology