Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infection
L. G. Miller, K. Chiok, C. Mariasoosai, I. Mohanty, S. Pandit, P. Deol, L. Mehari, M. N. Teng, A. L. Haas, S. Natesan, T. A. Miura, S. Bose
This study identifies extracellular ISG15 as a soluble antiviral factor that promotes IFN-independent ISGylation through integrin-FAK pathway activation during virus infection.
bioRxiv · Jul 5, 2024 · PreprintImmunology