The paper develops a one-step genome editing method for Snodgrassella alvi, enabling gene knockouts and insertions with high accuracy and validation of mutant phenotypes.

bioRxiv · Sep 19, 2023 · PreprintMicrobiology

Bayesian modeling of the impact of antibiotic resistance on the efficiency of MRSA decolonization

F. Ojala, M. R. A. Sater, L. G. Miller, J. A. McKinnell, S. S. Huang, Y. H. Grad, P. Marttinen

This study uses a Bayesian mixed effects survival model to show that mupirocin resistance in MRSA strains reduces decolonization success, while other resistances and subject-specific factors do not.

bioRxiv · Jan 25, 2023Microbiology

Proinflammatory responses in SARS-CoV-2 infected and soluble spike glycoprotein S1 subunit activated human macrophages

K. Chiok, K. Hutchison, L. G. Miller, S. Bose, T. A. Miura

This study shows that soluble SARS-CoV-2 Spike S1 subunit activates human macrophages to produce pro-inflammatory mediators, independent of viral replication.

bioRxiv · Jun 14, 2021Immunology

The Metabolic Capability and Phylogenetic Diversity of Mono Lake During a Bloom of the Eukaryotic Phototroph Picocystis strain ML

B. W. Stamps, H. S. Nunn, V. A. Petryshyn, R. S. Oremland, L. G. Miller, M. Rosen, K. W. Bauer, K. J. Thompson, E. M. Tookmanian, A. R. Waldeck, S. J. Lloyd, H. A. Johnson, B. S. Stevenson, W. Berelson, F. A. Corsetti, J. R. Spear

The paper investigates microbial dynamics during a natural algal bloom in Mono Lake, finding oxygenic photosynthesis occurs at depth despite anoxic conditions and reduced grazing pressure on Picocystis.

bioRxiv · May 30, 2018Microbiology