S. Bose

Androgen receptor plays critical role in regulating cervical cancer cell migration

This study identifies the androgen receptor as a key regulator in cervical cancer cell migration through network biology and experimental validation.

Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infection

This study identifies extracellular ISG15 as a soluble antiviral factor that promotes IFN-independent ISGylation through integrin-FAK pathway activation during virus infection.

A chemically-induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

The paper attenuates Candida albicans using EDTA to create a live vaccine candidate that induces protective immunity and prevents systemic candidiasis in mice.

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian Cells

This study identifies TTF1 as an interactor of DDB1 and shows its role in UV-induced DNA damage repair through co-localization with γH2AX and reciprocal regulation of DDB1 levels.

Biochemical characterization of a GDP-mannose transporter from Chaetomium thermophilum

The paper characterizes CtVrg4, a GDP-mannose transporter from Chaetomium thermophilum, showing enhanced thermal stability and phosphatidylinositol lipid binding.

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha

This study identifies RBM43 as a regulator of PGC1alpha translation, linking adipose inflammation to reduced energy expenditure and mitochondrial function in obesity.

G6PD Inhibition Sensitizes Ovarian Cancer Cells to Oxidative Stress in the Metastatic Omental Microenvironment

This study shows G6PD inhibition increases oxidative stress and reduces omental metastases in ovarian cancer.

Opportunistic gut sampling indicates differential diet and plastic ingestion risk in Indian dugongs

The paper analyzes gut contents of stranded Indian dugongs to compare seagrass diet and plastic ingestion risk between Tamil Nadu and Gujarat.

Proinflammatory responses in SARS-CoV-2 infected and soluble spike glycoprotein S1 subunit activated human macrophages

This study shows that soluble SARS-CoV-2 Spike S1 subunit activates human macrophages to produce pro-inflammatory mediators, independent of viral replication.

Substrate mediated elastic coupling between motile cells modulates inter-cell interactions and enhances cell-cell contact

The paper builds a biophysical model to study how substrate deformation mediates cell-cell interactions and influences collective cell behavior during migration.

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

The Na+/K+ ATPase Regulates Glycolysis and Modifies Immune metabolism in Tumors

This study shows that Na+/K+ ATPase inhibition via digoxin disrupts glycolysis in tumor and healthy cells, alters immune metabolism, and changes tumor microenvironment composition.