Author

P. Dupuy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

M. Glickman· 2 shared M. S. Glickman· 2 shared O. O. Adefisayo· 2 shared S. Ghosh· 2 shared S. Shuman· 2 shared J. Bean· 1 shared J. Buglino· 1 shared J. M. Bean· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

M. Glickman

Mutual co-authors in cluster

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4 papers

Recent·Most cited

The C-terminal acid phosphatase module of the RNase HI enzyme RnhC controls rifampicin sensitivity and light-dependent colony pigmentation of Mycobacterium smegmatis.

M. Glickman, P. Dupuy

The study identifies the C-terminal acid phosphatase domain of RnhC as critical for rifampicin resistance and pigmentation in M. smegmatis, independent of RNase HI activity.

bioRxiv · Nov 9, 2022 · PreprintMicrobiology

Pleiotropic roles for mycobacterial DinB2 in frameshift and substitution mutagenesis

P. Dupuy, S. Ghosh, O. Adefisayo, J. Bean, R. Gupta, S. Shuman, M. Glickman

This study investigates the mutagenic roles of mycobacterial DinB2, showing it drives substitution and frameshift mutations, and becomes more mutagenic with manganese.

bioRxiv · Aug 14, 2022Microbiology

Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis.

P. Dupuy, S. Ghosh, O. O. Adefisayo, J. Buglino, S. Shuman, M. S. Glickman

This study identifies DinB1 and DnaE2 as distinct contributors to mycobacterial genome diversification through frameshift and missense mutations, with implications for antibiotic resistance.

bioRxiv · Mar 6, 2022Microbiology

Division of Labor between SOS and PafBC in Mycobacterial DNA Repair and Mutagenesis

O. O. Adefisayo, P. Dupuy, J. M. Bean, M. S. Glickman

This study investigates the functional roles of SOS and PafBC pathways in mycobacterial DNA repair and mutagenesis, revealing their distinct and overlapping contributions to antibiotic resistance.

bioRxiv · Aug 5, 2021Microbiology