NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylation
F. Dominguez, N. Shiliaev, T. Lukash, P. Agback, O. Palchevska, J. R. Gould, C. D. Meshram, P. E. Prevelige, T. J. Green, T. Agback, E. I. Frolova, I. Frolov
This study identifies NAP1L1 and NAP1L4 as host factors that bind to the phosphorylated hypervariable domain of CHIKV nsP3, enhancing viral replication through bivalent interactions.
bioRxiv · May 19, 2021Microbiology