Author

I. Frolov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:fungi (other)· 1 Organism:human· 1

Frequent Co-Authors

E. I. Frolova· 3 shared F. Dominguez· 3 shared N. Shiliaev· 3 shared O. Palchevska· 3 shared T. Lukash· 3 shared P. Agback· 2 shared T. Agback· 2 shared T. J. Green· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMicrobiology

E. I. Frolova

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Alphavirus-induced transcriptional and translational shutoffs play major roles in blocking the formation of stress granules

O. Palchevska, F. Dominguez, E. I. Frolova, I. Frolov

This study shows that alphavirus-induced transcriptional and translational shutoffs, not nsP3 interactions with G3BP1/2 or ADP-ribosylhydrolase activity, are the main factors inhibiting stress granule formation.

bioRxiv · Jul 5, 2023 · PreprintMicrobiology

Introgressive descent and hypersexuality drive the evolution of sexual parasitism and morphological reduction in a fungal species complex.

F. Fernandez-Mendoza, E. Strasser, I. Frolov, J. Vondrak, L. Muggia, H. Mayrhofer, E. Gaya, M. Grube

The paper shows hybridization explains morphological and genetic diversity in Pyrenodesmia fungi, with genome defense mechanisms and RIP shaping genomic stability and morphological reduction.

bioRxiv · Jan 10, 2023 · PreprintEvolutionary Biology

Natural isolate and recombinant SARS-CoV-2 rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavage

N. Shiliaev, T. Lukash, O. Palchevska, D. K. Crossman, T. J. Green, M. Crowley, E. I. Frolova, I. Frolov

This study shows that SARS-CoV-2 rapidly evolves in vitro to bind heparan sulfate more efficiently and reduce S1/S2 cleavage, increasing infectivity and decreasing GE:PFU ratios.

bioRxiv · Jun 28, 2021Microbiology

NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylation

F. Dominguez, N. Shiliaev, T. Lukash, P. Agback, O. Palchevska, J. R. Gould, C. D. Meshram, P. E. Prevelige, T. J. Green, T. Agback, E. I. Frolova, I. Frolov

This study identifies NAP1L1 and NAP1L4 as host factors that bind to the phosphorylated hypervariable domain of CHIKV nsP3, enhancing viral replication through bivalent interactions.

bioRxiv · May 19, 2021Microbiology

Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein

T. Lukash, T. Agback, F. Dominguez, N. Shiliaev, C. Meshram, E. Frolova, P. Agback, I. Frolov

This study identifies FHL1 as a host factor interacting with CHIKV nsP3 HVD, showing it stimulates replication but is not essential, and highlights additive pro-viral effects with CD2AP.

bioRxiv · Sep 29, 2020Microbiology