Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response
A. Prabhakar, R. Kumar, M. Wadhwa, P. Ghatpande, J. Zhang, Z. Zhao, C. O. Lizama, B. N. Kharbikar, S. Graf, C. M. Treacy, N. W. Morrell, B. B. Graham, G. Lagna, A. Hata
This study shows that inhibiting the integrated stress response (ISR) or PKR reduces vascular remodeling in PVOD models, suggesting potential therapeutic strategies.
bioRxiv · Nov 27, 2023 · PreprintCell Biology