Author

C. O. Lizama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:development & morphogenesis· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. Atabai· 3 shared C. D. Yang· 2 shared G. L. McKinsey· 2 shared M. J. Podolsky· 2 shared N. Santander· 2 shared R. Datta· 2 shared T. D. Arnold· 2 shared A. A. Chang· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersPhysiology

K. Atabai

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

A. Prabhakar, R. Kumar, M. Wadhwa, P. Ghatpande, J. Zhang, Z. Zhao, C. O. Lizama, B. N. Kharbikar, S. Graf, C. M. Treacy, N. W. Morrell, B. B. Graham, G. Lagna, A. Hata

This study shows that inhibiting the integrated stress response (ISR) or PKR reduces vascular remodeling in PVOD models, suggesting potential therapeutic strategies.

bioRxiv · Nov 27, 2023 · PreprintCell Biology

Radial glia promote microglial development through integrin aVb8 -TGFb1 signaling

G. L. McKinsey, N. Santander, X. Zhang, K. Kleemann, L. Tran, A. Katewa, K. Conant, M. Barraza, K. Waddell, C. O. Lizama, M. La Russa, J. H. Koo, H. Lee, D. Mukherjee, H. Paidassi, , T. D. Arnold

This study shows radial glia use integrin aVb8-TGFb1 signaling to promote microglial development, with disruptions causing dysmature microglia and neuromotor symptoms.

bioRxiv · Jul 13, 2023Immunology

MFGE8 inhibits insulin signaling through PTP1B

R. Datta, M. J. Podolsky, C. D. Yang, D. Alba, S. Singh, S. Koliwad, C. O. Lizama, K. Atabai

This study shows MFGE8 inhibits insulin signaling by promoting PTP1B binding to and dephosphorylation of IR{beta}, reducing glucose uptake, and identifies a correlation between serum MFGE8 levels and insulin resistance in humans.

bioRxiv · May 30, 2023 · PreprintPhysiology

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

J. Sbierski-Kind, K. M. Cautivo, J. Wagner, M. W. Dahlgren, J. Nilsson, M. Krasilnikov, N. M. Mroz, C. O. Lizama, A. L. Gan, P. R. Matatia, M. T. Taruselli, A. A. Chang, S. Caryotakis, C. O'Leary, M. Kotas, , A. B. Molofsky

The paper investigates the role of IL-5+ lymphocytes and type 3/17 lymphocytes in liver fibrosis, showing their spatial relationship and cross-regulation in fibroblast niches.

bioRxiv · Apr 26, 2023 · PreprintImmunology

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes

R. Datta, M. A. Gholampour, C. D. Yang, R. Volk, S. Lin, M. J. Podolsky, T. Arnold, F. Rieder, B. W. Zaro, M. Verzi, R. Lehner, N. Abumrad, C. O. Lizama, K. Atabai

This study identifies CES1D as the hydrolase downstream of the MFGE8-vβ5 integrin pathway that regulates catabolism of diet-derived lipid droplets in enterocytes.

bioRxiv · May 16, 2022Physiology

New Tools for Genetically Targeting Myeloid Populations in the Central Nervous System

G. L. McKinsey, C. O. Lizama, A. E. Keown-Lang, A. Niu, E. Chee, N. Santander, T. D. Arnold

The paper introduces two genetic tools to specifically target distinct CNS macrophage subtypes, including parenchymal microglia and borderzone macrophages.

bioRxiv · Dec 20, 2019Immunology