Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression
Y. Bi, V. S. Shirure, R. Liu, C. Cunningham, L. Ding, M. Meacham, P. Goedegebuure, S. C. George, R. C. Fields
This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.
bioRxiv · May 27, 2020Cancer Biology