S. C. George

A microfluidic strategy to capture antigen-specific high affinity B cells

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

Krumholzibacteriota and Deltaproteobacteria contain rare genetic potential to liberate carbon from monoaromatic compounds in subsurface coal seams

This study identifies three microbial taxa with genetic potential to degrade monoaromatic compounds in subsurface coal seams, including a novel Krumholzibacteriota species.

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

Convection and extracellular matrix binding control interstitial transport of extracellular vesicles

This study shows that convection and ECM binding are the main mechanisms controlling EV transport in interstitial fluid, with implications for nanotherapeutic design.

Automated protein-protein structure prediction of the T cell receptor-peptide major histocompatibility complex

The paper presents a pipeline to predict TCR-pMHC structures and rank TCRs for immunotherapeutic applications using computational methods.

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

This paper develops a vascularized 3D model of human pancreatic islets to study immune cell interactions and islet destruction in diabetes.

T Cell Receptor Non-Equilibrium Kinetics

This study shows that mutations in pMHC binding groove peptides affect TCR-pMHC bond strength and duration, correlating with immunogenicity through physiochemical features.

The Atomic-Level Physiochemical Determinants of T Cell Receptor Dissociation Kinetics

This study identifies physiochemical features of TCRs that influence dissociation kinetics using SMD and machine learning, showing hydrogen bonds in specific regions are critical for bond lifetime and immunogenicity.

Exploiting synergistic interactions of Medicago sativa L. and Paraburkholderia tropica for enhanced biodegradation of diesel fuel hydrocarbons

This study examines the synergistic interactions between Medicago sativa and Paraburkholderia tropica to enhance diesel fuel hydrocarbon degradation in contaminated soils.

Metagenomic insight into the plant growth-promoting potential of a diesel-degrading bacterial consortium for enhanced rhizoremediation application

The paper identifies a bacterial consortium capable of promoting plant growth and degrading diesel fuel hydrocarbons, showing potential for rhizoremediation applications.

Diversity and metagenome analysis of a hydrocarbon-degrading bacterial consortium from asphalt lakes located in Wietze, Germany

This study isolates and analyzes a hydrocarbon-degrading bacterial consortium from a petroleum-contaminated site, identifying Acidocella as a key genus for diesel fuel degradation.

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

Organ-on-a-chip model of vascularized human bone marrow niches

This study develops a 3D organ-on-a-chip model of human bone marrow niches that supports hematopoietic stem cell maintenance, differentiation, and myeloid progenitor egress.