Author

P. H. O'Farrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Organism:Drosophila· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Approach:benchmark study· 1

Frequent Co-Authors

C.-Y. Cho· 3 shared C. A. Seller· 1 shared E. Korotkevich· 1 shared J. P. Kemp· 1 shared P.-I. Tsai· 1 shared R. J. Duronio· 1 shared

Activity by Year

2022-2022 · peak 4/yr

Co-Author Collaboration Network

6 top collaborators · 5 mutual co-author links

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3 shared papersCell Biology

C.-Y. Cho

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription

C.-Y. Cho, P. H. O'Farrell

The paper shows that pioneer factor Zelda, with dCBP, nucleates dBrd4 hubs that trigger RNAPII clustering, leading to a burst of transcription in Drosophila embryos.

bioRxiv · Nov 8, 2022Cell Biology

Mitigation of the age-dependent decline in mitochondrial genome integrity

P.-I. Tsai, E. Korotkevich, P. H. O'Farrell

This study shows that quality control mechanisms reduce mitochondrial DNA mutations in development but fail during aging, and pharmacological interventions can reverse age-related mtDNA deterioration in flies and mice.

bioRxiv · Jan 18, 2022Cell Biology

Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila

C.-Y. Cho, C. A. Seller, P. H. O'Farrell

This paper shows Rif1-PP1 hubs in Drosophila embryos control late replication timing by stabilizing and dispersing in response to kinase activity, coordinating origin firing.

bioRxiv · Jan 14, 2022Cell Biology

Mandatory coupling of zygotic transcription to DNA replication in early Drosophila embryos

C.-Y. Cho, J. P. Kemp, R. J. Duronio, P. H. O'Farrell

The paper shows that zygotic transcription in Drosophila embryos is coupled to DNA replication to avoid collisions between RNA polymerases and replication forks.

bioRxiv · Jan 4, 2022Cell Biology