Author

P.-I. Tsai

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Cell Biology· 1

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Approach:benchmark study· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

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E. Korotkevich· 1 shared P. H. O'Farrell· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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1 shared paperCell Biology

E. Korotkevich

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1 paper

Recent·Most cited

Mitigation of the age-dependent decline in mitochondrial genome integrity

P.-I. Tsai, E. Korotkevich, P. H. O'Farrell

This study shows that quality control mechanisms reduce mitochondrial DNA mutations in development but fail during aging, and pharmacological interventions can reverse age-related mtDNA deterioration in flies and mice.

bioRxiv · Jan 18, 2022Cell Biology