Intestinal infection results in impaired lung innate immunity to secondary respiratory infection.
S. Trivedi, A. H. Grossmann, O. Jensen, M. J. Cody, T. A. Wahlig, P. H. Serpa, C. Langelier, K. J. Warren, C. C. Yost, D. T. Leung
This study shows that prior intestinal infection with Salmonella Typhimurium increases susceptibility to respiratory Klebsiella pneumoniae infection due to altered neutrophil responses in the lungs.
bioRxiv · Aug 3, 2020Immunology