S. Trivedi

Distinct intersecting pathways link homolog pairing to initiation of meiotic chromosome synapsis

This study identifies BRA-2 and HIM-17 as distinct factors involved in meiotic synapsis licensing and homolog pairing in C. elegans.

MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth

This study shows MAIT cells inhibit colon cancer growth in mice by modulating immune responses and increasing eosinophil-related cytokines.

Increasing Chemotherapeutic Efficacy Using pH Modulating and Doxorubicin Releasing Injectable Chitosan-Polyethylene Glycol Hydrogels

This paper develops a hydrogel that delivers doxorubicin and sodium bicarbonate to neutralize tumor acidity and enhance chemotherapy efficacy.

Use of a MAIT activating ligand, 5-OP-RU, as a mucosal adjuvant in a murine model of Vibrio cholerae O1 vaccination.

This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.

A novel subset of follicular helper-like MAIT cells has capacity for B cell help and antibody production in the mucosa.

The paper identifies and characterizes a novel subset of T follicular helper-like MAIT cells that can provide B cell help and promote IgA antibody production in mucosal immunity.

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection.

This study shows that prior intestinal infection with Salmonella Typhimurium increases susceptibility to respiratory Klebsiella pneumoniae infection due to altered neutrophil responses in the lungs.

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

This study shows MAIT cells are activated and dysfunctional in sepsis, contributing to protective cytokine responses in experimental sepsis but reduced in clinical cases.