D. T. Leung

MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth

This study shows MAIT cells inhibit colon cancer growth in mice by modulating immune responses and increasing eosinophil-related cytokines.

Enhancing Mucosal-Associated Invariant T (MAIT) cell function and expansion with human selective serum

This study compares the effects of Physiologix XF SR and fetal bovine serum on MAIT cell expansion, finding that Phx enhances proliferative capacity and functional responses.

Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury

This study identifies T cell alterations in burn skin tissue using multi-omic analysis, showing increased pro-inflammatory activity and cytotoxic capacity in unconventional T cells.

Use of a MAIT activating ligand, 5-OP-RU, as a mucosal adjuvant in a murine model of Vibrio cholerae O1 vaccination.

This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

A novel subset of follicular helper-like MAIT cells has capacity for B cell help and antibody production in the mucosa.

The paper identifies and characterizes a novel subset of T follicular helper-like MAIT cells that can provide B cell help and promote IgA antibody production in mucosal immunity.

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection.

This study shows that prior intestinal infection with Salmonella Typhimurium increases susceptibility to respiratory Klebsiella pneumoniae infection due to altered neutrophil responses in the lungs.

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

This study shows MAIT cells are activated and dysfunctional in sepsis, contributing to protective cytokine responses in experimental sepsis but reduced in clinical cases.