Author

P. Hugues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Bennaceur Griscelli· 2 shared C. Desterke· 2 shared A. Foudi· 1 shared A. G. Turhan· 1 shared A. Turhan· 1 shared I. Simanic· 1 shared J. Artus· 1 shared J. C. Chomel· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. Bennaceur Griscelli

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2 papers

Recent·Most cited

miR-495-3p Sensitizes BCR::ABL1 Expressing Leukemic cells to Tyrosine Kinase Inhibitors by Targeting Multidrug Resistance 1 Gene including in T315I Mutated cells

Y. Rittavee, J. Artus, C. Desterke, I. Simanic, L. Eduardo Botelho de Souza, S. Riccaldi, S. Coignard, Y. Ijjeh, P. Hugues, A. Bennaceur Griscelli, A. G. Turhan, A. Foudi

This study shows miR-495-3p reduces CML cell growth and TKI resistance by targeting MDR1, especially in T315I-mutant cells, and identifies it as a potential therapeutic target.

Experimental Hematology · Feb 1, 2023Peer-reviewedCancer Biology

Evidence of massive leukemic progenitor expansion in blood during molecular recurrence after TKI discontinuation in chronic myeloid leukemia (CML)

A. Turhan, P. Hugues, N. Sorel, C. Desterke, J. H. Bourhis, A. Bennaceur Griscelli, J. C. Chomel

The paper shows that leukemic progenitor expansion occurs in peripheral blood before cytological changes in CML patients after TKI discontinuation.

bioRxiv · Oct 22, 2019Cancer Biology