P. I. Giammarinaro

This study shows VirB, a virulence regulator in Shigella flexneri, uses CTP binding and hydrolysis to control DNA binding and sliding, thereby regulating gene expression.

The paper solves the structure of the bacterial HARP from Halorhodospira halophila and shows that oligomerization is required for RNase P activity, revealing a novel screw-like dodecameric assembly and substrate binding mechanism.