Structure and mechanistic features of the prokaryotic minimal RNase P
R. Feyh, N. B. Waeber, S. Prinz, P. I. Giammarinaro, G. Bange, G. Hochberg, R. K. Hartmann, F. Altegoer
The paper solves the structure of the bacterial HARP from Halorhodospira halophila and shows that oligomerization is required for RNase P activity, revealing a novel screw-like dodecameric assembly and substrate binding mechanism.
bioRxiv · May 7, 2021Biochemistry