G. Bange

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

The role of chloroplast SRP54 domains and its C-terminal tail region in post- and cotranslational protein transport in vivo

This study investigates the role of cpSRP54 domains and its C-terminal tail in chloroplast protein transport, showing their importance in post- and cotranslational transport of photosynthetic proteins.

Polar confinement of a macromolecular machine by an SRP-type GTPase

This study identifies how FlhF and FlhG regulate flagellar assembly by anchoring structures to the cell pole via interactions with HubP and FliG.

The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression

This study shows VirB, a virulence regulator in Shigella flexneri, uses CTP binding and hydrolysis to control DNA binding and sliding, thereby regulating gene expression.

HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids.

This study identifies two distinct mechanisms by which HilD activity is repressed: LCFAs bind to a conserved pocket, while HilE forms a heterodimer with HilD.

Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells

The paper develops a peptide inhibitor targeting the Elongin BC dimer, showing reduced cancer cell viability and increased apoptosis by blocking its interaction partners.

Structural and functional analysis of YopR and identification of an additional key component of the SPβ phage lysis-lysogeny management system

The paper identifies YopR and YosL as key components of the SPβ phage lysis-lysogeny system, showing YopR's DNA-binding role and YosL's necessity for lytic cycle induction.

Selective accumulation of matrix proteins inside of peroxisomal subdomains

The paper identifies a peptide motif that drives peroxisomal subdomain formation in fungi and shows this mechanism is conserved in mammalian peroxisomes and mitochondria.

Structural and functional analysis of the cerato-platanin-like effector protein Cpl1 suggests diverging functions in smut fungi

The paper presents the atomic structures of Cpl1 and Uvi2 from smut fungi, revealing their chitin-binding properties and suggesting diverging functions through structural differences.

A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein

The paper shows how the GGDEF domain of PdeB acts as a spatial on-switch by interacting with HubP to restrict phosphodiesterase activity to the flagellated cell pole, influencing surface interaction and environmental spreading.

Structure and mechanistic features of the prokaryotic minimal RNase P

The paper solves the structure of the bacterial HARP from Halorhodospira halophila and shows that oligomerization is required for RNase P activity, revealing a novel screw-like dodecameric assembly and substrate binding mechanism.

The CTPase activity of ParB acts as a timing mechanism to control the dynamics and function of prokaryotic DNA partition complexes

This study identifies how ParB's CTPase activity regulates DNA partition complex dynamics and function by controlling clamp sliding time and spreading.

Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti

This study identifies and characterizes Rgs proteins and the Tol-Pal system in S. meliloti, showing their roles in unipolar growth and cell division.

Molecular architecture of the DNA-binding sites of the P-loop ATPases MipZ and ParA from Caulobacter crescentus

This study identifies the DNA-binding residues of MipZ and ParA from Caulobacter crescentus, revealing sequence-independent electrostatic interactions and conserved binding mechanisms across ParA-like ATPases.

The alarmone (p)ppGpp is part of the heat shock response of Bacillus subtilis

This study shows that (p)ppGpp, a bacterial alarmone, mediates the heat shock response in B. subtilis by reducing translation and enhancing stress tolerance.

Hampered motility promotes the evolution of wrinkly phenotype in Bacillus subtilis

The paper shows that non-motile Bacillus subtilis mutants evolve matrix overproducers with a wrinkly phenotype due to SinR mutations, which enhance exopolysaccharide production and biofilm formation in the absence of flagella.