G. Hochberg

2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

This study shows that 2-oxoglutarate induces dodecamer assembly of Methanosarcina mazei glutamine synthetase, enhancing its activity through a cooperative mechanism.

Characterisation of the SUF FeS cluster machinery in the amitochondriate eukaryote Monocercomonoides exilis

This study characterizes the SUF FeS cluster machinery in the amitochondriate eukaryote Monocercomonoides exilis, showing it can replace the mitochondrial ISC system in bacteria.

A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire

The paper describes the structure and function of a bacterial tungsten-containing aldehyde oxidoreductase, revealing its nanowire-like filament formation and catalytic mechanism.

ATPase activity of B. subtilis RecA affects the dynamic formation of RecA filaments at DNA double strand breaks

This study shows that ATPase activity in B. subtilis RecA is critical for dynamic filament formation at DNA breaks, while ATP binding is less essential for filament stability and basic function.

A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein

The paper shows how the GGDEF domain of PdeB acts as a spatial on-switch by interacting with HubP to restrict phosphodiesterase activity to the flagellated cell pole, influencing surface interaction and environmental spreading.

Structure and mechanistic features of the prokaryotic minimal RNase P

The paper solves the structure of the bacterial HARP from Halorhodospira halophila and shows that oligomerization is required for RNase P activity, revealing a novel screw-like dodecameric assembly and substrate binding mechanism.