Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling
Gaurav D. Sankhe, Rubesh Raja, Devendra Pratap Singh, Sneha Bheemireddy, Subinoy Rana, P. J. Athira, Narendra M. Dixit, Deepak Kumar Saini
The paper shows that non-cognate response regulators sequester phosphorylated histidine kinases, establishing a threshold for bacterial two-component signaling to prevent over-response to weak signals.
Nature Communications · Jul 25, 2023Peer-reviewedSystems Biology