Gaurav D. Sankhe

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

This study shows that ligand binding inhibits dimerization of the bacterial histidine kinase PdtaS, thereby repressing its activity and multi-ligand sensing.

Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling

The paper shows that non-cognate response regulators sequester phosphorylated histidine kinases, establishing a threshold for bacterial two-component signaling to prevent over-response to weak signals.