Author

P. J. Lein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1

Frequent Co-Authors

A. K. Ehrlich· 1 shared C. A. Martinez· 1 shared D. J. Harvey· 1 shared F. d. C. Souza· 1 shared G. A. Cherednychenko· 1 shared H.-J. Lehmler· 1 shared I. Pessah· 1 shared J. A. MacMahon· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

A. K. Ehrlich

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PCB-Exposed Gut Microbiota Recapitulate Neurobehavioral Deficits and Reprogram Hippocampal Transcriptomic Signatures

Y. P. Suh, R. J. Wilson, N. M. Breese, P. J. Lein, H.-J. Lehmler, Julia Yue Cui

This study shows that transferring PCB-exposed gut microbiota to offspring reproduces neurobehavioral deficits and induces sex-biased molecular changes in the brain.

bioRxiv · Nov 9, 2026 · PreprintPharmacology & Toxicology

The alpha4 nicotinic acetylcholine receptor is necessary for the initiation of organophosphate-induced neuronal hyperexcitability

P. M. Andrew, W. Feng, J. J. Calsbeek, S. P. Antrobus, G. A. Cherednychenko, J. A. MacMahon, P. N. Bernardino, X. Liu, D. J. Harvey, P. J. Lein, I. Pessah

This study shows that alpha4 nicotinic acetylcholine receptors are required for organophosphate-induced neuronal hyperexcitability in vitro and in vivo.

bioRxiv · Jan 24, 2024Pharmacology & Toxicology

Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4+ T cells

S. Sandoval, K. Malany, K. Thongphanh, C. A. Martinez, M. L. Goodson, F. d. C. Souza, L.-W. Lin, J. Pennington, P. J. Lein, N. I. Kerkvliet, A. K. Ehrlich

This study shows that AhR activation inhibits Nrp1 upregulation on activated CD4+ T cells, particularly in proliferating cells and those stimulated with IL-2.

bioRxiv · Sep 25, 2023Immunology

Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate zebrafish larvae exposure method

P. C. Mundy, R. Mendieta, P. J. Lein

The paper shows DFP volatilizes and cross-contaminates wells in a 96-well plate zebrafish larvae exposure method, affecting experimental outcomes.

bioRxiv · Jul 19, 2021 · PreprintPharmacology & Toxicology