Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant
J.-J. Tong, U. Khan, B. G. Haddad, P. J. Minogue, E. C. Beyer, V. M. Berthoud, S. L. Reichow, L. Ebihara
This paper investigates the functional and structural properties of a cataract-associated Cx50 mutant, showing it causes enhanced hemichannel currents and cytotoxicity through altered voltage-gating and electrostatic interactions.
bioRxiv · Aug 18, 2021Physiology