Author

B. G. Haddad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

S. L. Reichow· 3 shared D. M. Zuckerman· 2 shared U. Khan· 2 shared B. Yue· 1 shared C. C. Yoshioka· 1 shared D. Bai· 1 shared E. C. Beyer· 1 shared H. Chen· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

S. L. Reichow

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3 papers

Recent·Most cited

Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant

J.-J. Tong, U. Khan, B. G. Haddad, P. J. Minogue, E. C. Beyer, V. M. Berthoud, S. L. Reichow, L. Ebihara

This paper investigates the functional and structural properties of a cataract-associated Cx50 mutant, showing it causes enhanced hemichannel currents and cytotoxicity through altered voltage-gating and electrostatic interactions.

bioRxiv · Aug 18, 2021Physiology

Connexin 46 and connexin 50 gap junction channel open stability and unitary conductance are shaped by structural and dynamic features of their N-terminal domains

B. Yue, B. G. Haddad, U. Khan, H. Chen, M. Atalla, Z. Zhang, D. M. Zuckerman, S. L. Reichow, D. Bai

This study investigates how structural and dynamic features of the N-terminal domains of connexin 46 and 50 influence gap junction channel stability and conductance through molecular dynamics simulations and electrophysiology.

bioRxiv · Jul 1, 2020Biophysics

Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 A

J. A. Flores, B. G. Haddad, K. A. Dolan, J. B. Myers, C. C. Yoshioka, J. Copperman, D. M. Zuckerman, S. L. Reichow

This study uses CryoEM to resolve the structure of connexin-46/50 gap junction channels in a lipid environment, revealing how lipid interactions stabilize the channel and influence its function.

bioRxiv · Apr 14, 2020Biophysics