Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
J. C. Tsai, L. E. Miller-Vedam, A. A. Anand, P. Jaishankar, H. C. Nguyen, A. R. Renslo, A. Frost, P. Walter
The paper determines the structure of eIF2B bound to ISRIB, revealing how it promotes eIF2B assembly and reverses eIF2 phosphorylation effects.
bioRxiv · Nov 24, 2017Biochemistry