Author

A. R. Renslo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Organism:human· 2 Assay:structural biology· 2 Organism:virus· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. K. Shoichet· 2 shared J. J. Irwin· 2 shared M. R. Arkin· 2 shared S. Gahbauer· 2 shared Y. Moroz· 2 shared A. A. Anand· 1 shared A. Ashworth· 1 shared A. Frost· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

B. K. Shoichet

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Author profile →

5 papers

Recent·Most cited

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

E. A. Fink, C. Bardine, S. Gahbauer, I. Singh, K. White, S. Gu, X. Wan, B. Ary, I. Glenn, J. O'Connell, H. O'Donnell, P. Fajtova, J. Lyu, S. Vigneron, N. J. Young, , C. S. Craik

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

bioRxiv · Jul 5, 2022Biophysics

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2

S. Gahbauer, G. J. Correy, M. Schuller, M. P. Ferla, Y. U. Doruk, M. Rachman, T. Wu, M. Diolaiti, S. Wang, J. Neitz, D. Fearon, D. S. Radchenko, Y. Moroz, J. J. Irwin, A. R. Renslo, , J. S. Fraser

The paper computationally designs and experimentally validates potent inhibitors of the SARS-CoV-2 Nsp3 Macrodomain, identifying 160 ligands and 152 crystal structures with submicromolar affinity.

bioRxiv · Jun 27, 2022Biophysics

Small molecule inhibitors of a human recombination-associated ATPase, RAD54

K. T. Ehmsen, K. K. H. Ang, W. D. Wright, J. L. Davies, Y. Younis, Y. Birman, C. Bryant, A. Gallardo-Godoy, A. R. Renslo, R. J. Neitz, M. R. Arkin, W.-D. Heyer

This study identifies small molecule inhibitors of the human RAD54 ATPase, which is involved in homologous recombination, and evaluates their effects on DNA repair and cancer cell survival.

bioRxiv · Apr 19, 2019 · PreprintBiochemistry

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

J. C. Tsai, L. E. Miller-Vedam, A. A. Anand, P. Jaishankar, H. C. Nguyen, A. R. Renslo, A. Frost, P. Walter

The paper determines the structure of eIF2B bound to ISRIB, revealing how it promotes eIF2B assembly and reverses eIF2 phosphorylation effects.

bioRxiv · Nov 24, 2017Biochemistry

A Liquid Chromatography-Mass Spectrometry Method For Screening Disulfide Tethering Fragments

K. K. Hallenbeck, J. Davies, C. Merron, P. Ogden, E. Sijbesma, C. Ottmann, A. R. Renslo, C. Wilson, M. R. Arkin

The paper refines an LC/MS-based method for screening covalent small-molecule binders to proteins, achieving fast and reliable screening over multiple projects.

bioRxiv · Aug 4, 2017Biophysics