Author

H. C. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Biophysics· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:protein folding & dynamics· 3 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Assay:cryo-EM· 2 Organism:human· 2 Organism:plant (other)· 2

Frequent Co-Authors

A. Frost· 4 shared A. A. Anand· 3 shared A. F. Brilot· 2 shared A. M. Smith· 2 shared A. N. Rizo· 2 shared C. M. Azumaya· 2 shared D. Diwanji· 2 shared F. Li· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

A. Frost

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Pigment Binding in The Light-Dependent Protochlorophyllide Oxidoreductase

P. Pesara, K. Szafran, H. C. Nguyen, A. Sirohiwal, D. A. Pantazis, M. Gabruk

This study compares two Pchlide binding modes in LPOR using simulations and mutagenesis, concluding that mode B, supported by new structural data, is thermodynamically favorable and challenges previous assumptions about the enzyme's mechanism.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

M. Gupta, C. M. Azumaya, M. Moritz, S. Pourmal, A. Diallo, G. E. Merz, G. M. Jang, M. Bouhaddou, A. Fossati, A. F. Brilot, D. Diwanji, E. Hernandez, N. Herrera, H. T. Kratochvil, V. L. Lam, , K. I Pawar

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

bioRxiv · May 10, 2021 · PreprintBiophysics

Photocatalytic plant LPOR forms helical lattices that shape membranes for chlorophyll synthesis

H. C. Nguyen, A. A. Melo, J. Kruk, A. Frost, M. Gabruk

This study reveals the atomic structure of LPOR assemblies and shows how they shape membranes and catalyze chlorophyll synthesis in plants.

bioRxiv · Aug 19, 2020Biophysics

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

M. Schoof, B. Faust, R. A. Saunders, S. Sangwan, V. V. Rezelj, N. Hoppe, M. Boone, C. Billesboelle, C. Puchades, C. M. Azumaya, H. T. Kratochvil, M. Zimanyi, I. Deshpande, J. Liang, S. Dickinson, , Barile-H

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

bioRxiv · Aug 8, 2020Biochemistry

Membrane constriction and thinning by sequential ESCRT-III polymerization

H. C. Nguyen, N. Talledge, J. McCullough, A. Sharma, F. R. Moss, J. H. Iwasa, M. D. Vershinin, W. I. Sundquist, A. Frost

This study determines the structures of ESCRT-III filaments to show how sequential polymerization by CHMP1B and IST1 drives membrane tubulation, constriction, and thinning.

bioRxiv · Oct 11, 2019Biophysics

Whole genome sequencing of 358 brown planthoppers uncovers the landscape of their migration and dispersal worldwide

Q.-L. Hu, J.-C. Zhuo, Y.-X. Ye, D.-T. Li, Y.-H. Lou, X.-Y. Zhang, X. Chen, S.-L. Wang, Z.-C. Wang, J.-B. Lu, N. Mizlan, H. C. Nguyen, S. S. Oo, T. Thet, P. N. Sharma, , C.-X. Zhang

This study sequenced 358 brown planthopper genomes to reveal genetic structure and dispersal patterns, identifying five genetic groups and highlighting Southeast Asia as a major source for East Asian populations.

bioRxiv · Oct 9, 2019 · PreprintEvolutionary Biology

Structural basis of eIF2B-catalyzed GDP exchange and phosphoregulation by the integrated stress response

A. A. Anand, L. R. Kenner, H. C. Nguyen, A. G. Myasnikov, C. J. Klose, L. A. McGeever, J. C. Tsai, L. E. Miller-Vedam, P. Walter, A. Frost

The paper reports cryoEM structures of eIF2 bound to eIF2B, revealing the mechanism of GDP exchange and phosphoregulation in the integrated stress response.

bioRxiv · Dec 22, 2018Biochemistry

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

J. C. Tsai, L. E. Miller-Vedam, A. A. Anand, P. Jaishankar, H. C. Nguyen, A. R. Renslo, A. Frost, P. Walter

The paper determines the structure of eIF2B bound to ISRIB, revealing how it promotes eIF2B assembly and reverses eIF2 phosphorylation effects.

bioRxiv · Nov 24, 2017Biochemistry