Epigenetic coordination of transcriptional and translational programs in hypoxia
K. Watt, B. Dauber, K. J. Szkop, L. Lee, P. Jovanovic, S. Chen, R. Palia, J. A. Vassalakis, T. T. Cooper, D. Papadopoli, L. Masvidal, M. Jewer, K. Tandoc, H. Plummer, G. A. Lajoie, , L.-M. Postovit
The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.
bioRxiv · Sep 16, 2023 · PreprintCancer Biology