Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute Cardiotoxicity.
P. Kawalec, M. D. Martens, J. T. Field, W. Mughal, A. M. Caymo, D. Chapman, B. Xiang, S. Ghavami, V. W. Dolinsky, J. Gordon
This study examines the effects of low- and high-dose doxorubicin on cardiac structure, function, and cell death pathways in mice, finding that high-dose DOX causes necrosis and autophagy inhibition, while low-dose activates caspase signaling.
bioRxiv · Jan 15, 2022Physiology