B. Xiang

Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute Cardiotoxicity.

This study examines the effects of low- and high-dose doxorubicin on cardiac structure, function, and cell death pathways in mice, finding that high-dose DOX causes necrosis and autophagy inhibition, while low-dose activates caspase signaling.

Identification of SSX2IP/Msd1 as a Wtip-binding partner by targeted proximity biotinylation

The paper identifies SSX2IP as a Wtip-binding partner using targeted proximity biotinylation and shows their interaction forms phase-separated aggregates.

The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice

This study shows that Tafazzin deficiency in pancreatic islets reduces insulin secretion and mitochondrial function under low-glucose conditions.

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

This study shows that berberine treatment reduces adiposity and improves cardiac and pancreatic function in offspring exposed to gestational diabetes mellitus.

Calcium ion chelation preserves platelet function during cold storage

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

ScRNA-seq discover cell cluster change under OAB: ACE2 expression reveal possible alternation of 2019-nCoV infectious pathway

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.