Author

V. W. Dolinsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

G. M. Hatch· 4 shared B. Xiang· 3 shared D. Chapman· 3 shared L. K. Cole· 3 shared M. D. Martens· 3 shared A. R. West· 2 shared C. Rampitsch· 2 shared G. C. Sparagna· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiochemistry

G. M. Hatch

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tissue Specific Knockout of the Cardiolipin Transacylase Enzyme TAFAZZIN in Both Liver and Pancreatic Beta Cells Protects Mice From Diet-Induced Obesity

L. K. Cole, V. W. Dolinsky, G. M. Hatch

This study shows that knocking out tafazzin in both liver and pancreatic beta cells protects mice from diet-induced obesity by reducing weight gain and fat accumulation.

bioRxiv · Apr 19, 2022 · PreprintBiochemistry

Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute Cardiotoxicity.

P. Kawalec, M. D. Martens, J. T. Field, W. Mughal, A. M. Caymo, D. Chapman, B. Xiang, S. Ghavami, V. W. Dolinsky, J. Gordon

This study examines the effects of low- and high-dose doxorubicin on cardiac structure, function, and cell death pathways in mice, finding that high-dose DOX causes necrosis and autophagy inhibition, while low-dose activates caspase signaling.

bioRxiv · Jan 15, 2022Physiology

Altered Cardiolipin Metabolism is Associated with Cardiac Mitochondrial Dysfunction in Pulmonary Vascular Remodeled Perinatal Rat Pups

L. K. Cole, G. C. Sparagna, V. W. Dolinsky, G. M. Hatch

This study examines phospholipid metabolism in perinatal rat pups with pulmonary vascular remodeling, finding altered cardiolipin and phosphatidylethanolamine levels linked to mitochondrial dysfunction and cardiac dysfunction.

bioRxiv · Oct 12, 2021Biochemistry

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

M. D. Martens, N. Seshadri, L. Nguyen, D. Chapman, E. S. Hensen, B. Xiang, L. Falk, A. Mendoza, S. Rattan, S. B. Gibson, R. Keijzer, A. D. Saleem, G. M. Hatch, C. A. Doucette, J. M. Karch, , J. W. Gordon

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

bioRxiv · Oct 9, 2020Cell Biology

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

L. K. Cole, M. Zhang, L. Chen, G. C. Sparagna, M. Vandel, B. Xiang, V. W. Dolinsky, G. M. Hatch

This study shows that berberine treatment reduces adiposity and improves cardiac and pancreatic function in offspring exposed to gestational diabetes mellitus.

bioRxiv · Jul 20, 2020Physiology

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation.

S. C. da Silva Rosa, M. D. Martens, J. T. Field, L. Nguyen, S. Kereliuk, Y. Hai, D. Chapman, W. Diehl-Jones, M. Aliani, A. R. West, J. Thliveris, S. Ghavami, C. Rampitsch, V. W. Dolinsky, J. Gordon

The paper shows that Nix-induced mitochondrial fission, mitophagy, and insulin resistance in myocytes are reversed by PKA phosphorylation.

bioRxiv · Feb 20, 2020Cell Biology