J. Gordon

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

This study reconstructs carbohydrate utilization pathways in human gut bifidobacteria, revealing strain-specific metabolic capabilities and validating them experimentally.

Assessment of Stiffness-Dependent Autophagosome Formation and Apoptosis in Embryonal Rhabdomyosarcoma Tumor Cells

This study evaluates how matrix stiffness affects autophagosome formation and apoptosis in embryonal rhabdomyosarcoma cells using GelMA hydrogels.

Prevotella copri-related effects of a therapeutic food for malnutrition

The paper investigates the role of Prevotella copri in mediating the metabolic effects of a therapeutic food for malnutrition using gnotobiotic mouse models and multi-omics analyses.

Incorporation of TRDV segments into TCR alpha chains

The paper identifies TRDV segments incorporated into TCR alpha chains in human and murine tumor models and shows their prevalence in 10X VDJ datasets.

Identification of tubulin polymerization inhibitors with a CRISPR-edited cell line with endogenous fluorescent tagging of β-tubulin and Histone 1

This study uses CRISPR-edited cells with fluorescent β-tubulin to identify three novel tubulin polymerization inhibitors from a kinase inhibitor library.

A cell-based, spike protein binding assay highlights differences in antibody neutralising capacity for SARS-CoV-2 variants

The paper develops a cell-based ACE2/spike protein binding assay to assess antibody neutralising capacity against SARS-CoV-2 variants and shows differential blocking activity of monoclonal antibodies.

Skeletal muscle-derived extracellular vesicles are altered with chronic contractile activity: a dynamic light scattering analysis

This study shows chronic contractile activity reduces the size and zeta potential of skeletal muscle-derived extracellular vesicles using dynamic light scattering.

Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute Cardiotoxicity.

This study examines the effects of low- and high-dose doxorubicin on cardiac structure, function, and cell death pathways in mice, finding that high-dose DOX causes necrosis and autophagy inhibition, while low-dose activates caspase signaling.

Comparison of Three Individual Identification Algorithms for Sperm Whales (Physeter macrocephalus) after Automated Detection

The paper compares three algorithms for identifying sperm whale individuals using fluke images, finding PIE v2 outperforms CurvRank v2 and DTW in accuracy.

Discovery of imidazole-based inhibitors of P. falciparum cGMP-dependent protein kinase

The paper identifies imidazole-based inhibitors of PfPKG with good potency and low hERG activity against multiple Plasmodium species.

Sperm and northern bottlenose whale interactions with deep-water trawlers in the western North Atlantic

This study documents interactions between sperm and northern bottlenose whales and deep-water trawlers in the western North Atlantic, suggesting possible population recovery from historical whaling.

Acidity and sulfur oxidation intermediate concentrations controlled by O2-driven partitioning of sulfur oxidizing bacteria in a mine tailings impoundment

The paper investigates sulfur oxidation by bacteria in a mine tailings impoundment, showing how oxygen drives niche partitioning among sulfur-oxidizing bacteria and affects acidity and thiosulfate levels.

Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase.

The paper reports the discovery and optimization of novel PfPKG inhibitors with good potency, low hERG activity, and anti-parasitic activity.

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15

This study determines the cryo-EM structures of SARS-CoV-2 Nsp15, revealing its active site interactions with uridine and conformational changes, which inform potential therapeutic targets.

Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation.

The paper shows that Nix-induced mitochondrial fission, mitophagy, and insulin resistance in myocytes are reversed by PKA phosphorylation.