Quinolinate promotes alternatively activated macrophage-induced immune tolerance in glioblastoma through the NMDA/PPARγ signaling axis
P. Kesarwani, S. Kant, Y. Zhao, P. Chinnaiyan
The paper identifies quinolinate as a metabolic checkpoint in glioblastoma that promotes immune tolerance via NMDA/PPARγ signaling and suggests kynureninase as a therapeutic target.
bioRxiv · Jul 12, 2022 · PreprintCancer Biology