Yap is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates Expression of Ctgf in Cardiomyocytes.
V. L. Nelson, A. L. Eadie, M. Madhu, M. J. Platt, T. PULINILKUNNIL, P. Kienesberger, J. A. Simpson, K. R. Brunt
The paper shows Yap signaling in cardiomyocytes is sensitive to L-isoleucine and regulates Ctgf expression, influencing myocardial adaptation after injury.
bioRxiv · Apr 25, 2024Pharmacology & Toxicology