Author

M. J. Platt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

J. A. Simpson· 2 shared A. L. Eadie· 1 shared B. G. Neel· 1 shared J. C. Yin· 1 shared K. R. Brunt· 1 shared M. Madhu· 1 shared P. H. Backx· 1 shared P. Kienesberger· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. A. Simpson

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2 papers

Recent·Most cited

Yap is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates Expression of Ctgf in Cardiomyocytes.

V. L. Nelson, A. L. Eadie, M. Madhu, M. J. Platt, T. PULINILKUNNIL, P. Kienesberger, J. A. Simpson, K. R. Brunt

The paper shows Yap signaling in cardiomyocytes is sensitive to L-isoleucine and regulates Ctgf expression, influencing myocardial adaptation after injury.

bioRxiv · Apr 25, 2024Pharmacology & Toxicology

Cellular Interplay and Cytokine Hierarchy Cause Pathological Cardiac Hypertrophy in RAF1-Mutant Noonan Syndrome

J. C. Yin, M. J. Platt, X. Tian, X. Wu, P. H. Backx, J. A. Simpson, T. Araki, B. G. Neel

This study shows that RAF1 mutations in Noonan syndrome cause cardiac hypertrophy through cytokine signaling from endothelial cells, with TNF/IL6 as potential therapeutic targets.

bioRxiv · Mar 30, 2017Cell Biology