T. Pulinilkunnil

Inhibiting BCKDK in triple-negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity

This study shows that inhibiting BCKDK in TNBC cells reduces protein translation, impairs mitochondrial function, and enhances doxorubicin-induced cell death.

Silencing branched-chain ketoacid dehydrogenase or treatment with branched-chain ketoacids ex vivo inhibits muscle insulin signaling

This study shows that BCKAs inhibit muscle insulin signaling and that reducing BCKA levels improves insulin signaling and mitochondrial respiration in skeletal muscle cells.