An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37
P. Kolesinski, K.-C. Wang, Y. Hirose, V. Nizet, P. Ghosh
The paper reveals how M87 protein from Streptococcus pyogenes interacts with LL-37 by unfolding its coiled coil to expose a hydrophobic core, neutralizing the antimicrobial peptide.
bioRxiv · Jan 11, 2022Microbiology