Y. Hirose

Structure of PSI-LHCI from Cyanidium caldarium provides evolutionary insights into conservation and diversity of red-lineage LHCs

The paper determines the structure of PSI-LHCI from Cyanidium caldarium and investigates its evolutionary relationships with other red-lineage LHCs.

Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins

The paper identifies carbon sources that regulate hemolytic toxin expression in Streptococcus pyogenes using transcriptome-wide independent component analysis.

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

The paper identifies a new class of covalent inhibitors for SARS-CoV-2 3CL protease with chlorofluoroacetamide warhead, showing potent antiviral activity comparable to nirmatrelvir.

Diaphorin, a polyketide produced by a bacterial symbiont of the Asian citrus psyllid, inhibits the growth of Bacillus subtilis but promotes the growth of Escherichia coli

The paper investigates the effects of diaphorin, a polyketide from a bacterial symbiont, on the growth of two bacterial species, finding it inhibits Bacillus subtilis but promotes Escherichia coli growth.

An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

The paper reveals how M87 protein from Streptococcus pyogenes interacts with LL-37 by unfolding its coiled coil to expose a hydrophobic core, neutralizing the antimicrobial peptide.

Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome

The paper reports cryo-EM structures of a thermophilic cyanobacterial phycobilisome, revealing protein subunit arrangements and energy transfer pathways.

Conservation and diversity in transcriptional responses among host plants forming distinct arbuscular mycorrhizal morphotypes

The paper investigates transcriptional responses to arbuscular mycorrhizal (AM) symbiosis and gibberellin (GA) treatment in three host plants with distinct AM morphotypes, finding conserved and divergent gene expression patterns.

A selective glucocorticoid receptor modulator attenuates lung inflammation and improves alveolarization in a neonatal rat model of bronchopulmonary dysplasia.

This study shows that Compound A reduces lung inflammation and improves alveolarization in a neonatal rat model of bronchopulmonary dysplasia.

Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE

This paper reports the crystal structure of RcaE's bilin-binding domain in the red-absorbing state and provides NMR evidence of bilin protonation states, elucidating the structural basis of the green/red photocycle in CBCRs.

Elucidation and control of low and high active populations of alkaline phosphatase molecules for quantitative digital bioassay

This study quantitatively analyzes single-molecule ALP activity, revealing two distinct populations with different catalytic properties and demonstrating methods to generate homogeneous ALP populations.

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.

Transcriptomic profiling of Streptococcus pyogenes M1T1 strain in a mouse model of necrotizing fasciitis

This study identifies S. pyogenes gene-expression changes in a mouse necrotizing fasciitis model, revealing upregulation of virulence factors and downregulation of oxidative-stress response genes.

Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA

This paper investigates the role of PfbA in Streptococcus pneumoniae pathogenesis, finding that it inhibits phagocytosis and modulates host inflammation, with differential effects in pneumonia and sepsis models.

Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae

The paper identifies a conserved virulence factor in Streptococcus pneumoniae through evolutionary analysis and shows its role in immune evasion.