Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation
A. Iannuzzo, S. Delafontaine, R. El Masri, R. Tacine, G. Prencipe, M. Nishitani-Isa, R. T. van Wijck, F. Bhuyan, A. A. d. J. Rasheed, S. Coppola, P. L. van Daele, A. Insalaco, R. Goldbach-Mansky, T. Yasumi, M. Tartaglia, , J. Delon
This study identifies Golgi-trapped CDC42 variants causing STING hyperactivation and IFN elevation in autoinflammatory patients.
bioRxiv · Jan 31, 2024 · PreprintImmunology