HIV-1 Vpu promotes phagocytosis of infected CD4+ T cells by macrophages through downregulation of CD47
L. Cong, S. M. Sugden, P. Leclair, C. J. Lim, T. N. Pham, E. A. Cohen
This study shows HIV-1 Vpu downregulates CD47 on infected CD4+ T cells, enhancing macrophage phagocytosis and enabling macrophage infection by T/F viruses.
bioRxiv · Mar 16, 2021Microbiology