Protecting Allogeneic Pancreatic Islet Grafts by Engineered Veto
Y. Qi, X. Zhang, J. W. Cull, P. McCoy, C. Cruz, K. Dahl, U. D. Staerz
This study uses adenoviral vectors to express CD8-TCR chains in pancreatic islets, enabling them to induce immune tolerance and protect against rejection without systemic immunosuppression.
bioRxiv · Jan 5, 2024 · PreprintImmunology