A. T. Papenfuss

The paper creates a comprehensive immune system map across age, sex, and ethnicity using single-cell RNA sequencing data, revealing immune ageing patterns and ethnic diversity in immune checkpoints.

The paper shows that mRNA decay rates determine the effectiveness of transcriptional inhibitors in leukemia, with short-lived mRNAs being more responsive and long-lived ones being modulated by RNA-binding proteins.

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

This paper shows that a G358S mutation in PfATP4 confers clinically relevant resistance to cipargamin and (+)-SJ733 in P. falciparum parasites.

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

This paper introduces LINX, a tool for analyzing structural variation and copy number alterations in cancer genomes, revealing novel insights into oncogenic fusions and inactivation events.

This study uses transcriptome sequencing and multiplex imaging to show that monocytic cells drive prostate cancer progression and immune modulation.

SVclone infers cancer cell fractions of structural variant breakpoints from whole-genome sequencing data and identifies subclonal copy-number neutral rearrangements linked to decreased survival in certain cancers.

The paper identifies somatic mutations in early metazoan genes that disrupt regulatory links between unicellular and multicellular genes in cancer, linking these mutations to drug response.