Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin
Y. Qian, T. Lei, P. Patel, C. Lee, P. Monaghan-Nichols, H.-B. Xin, J. Qiu, M. Fu
This study identifies SARS-CoV-2 nucleocapsid protein as a potent activator of human endothelial cells, showing that simvastatin inhibits this activation through TLR2/NF-κB and MAPK pathways.
bioRxiv · Feb 14, 2021Immunology