P. O'Callaghan

The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signalling

The paper investigates Ca2+ dynamics in β-cell primary cilia and identifies GABA-B1 receptor-mediated paracrine signaling as a localized Ca2+ signaling mechanism.

Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

This study shows that Piezo1 activation reduces thrombin-induced blebbing in breast cancer cells by increasing cytosolic calcium and modulating ERM protein phosphorylation.