G. Sanchez

Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

ddRAD-seq-derived SNPs reveal novel association signatures for fruit-related traits in peach

This study uses ddRAD-seq SNPs to identify 16 association signals for six fruit-related traits in peach, with one marker linked to both harvest date and fruit firmness.

Tissue-specific collagen hydroxylation at GEP/GDP triplets mediated by P4HA2

The paper compares collagen hydroxylation patterns in bone, skin, and tendon, finding tissue-specific regulation mediated by P4HA2.

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

This study identifies X chromosome dosage and DHA reduction as drivers of statin-induced dysglycemia and mitochondrial dysfunction in females.

The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signalling

The paper investigates Ca2+ dynamics in β-cell primary cilia and identifies GABA-B1 receptor-mediated paracrine signaling as a localized Ca2+ signaling mechanism.

PAF1 facilitates RNA polymerase II ubiquitination by the Elongin A complex through phosphorylation by CDK12

The paper shows PAF1 interacts with Elongin A to ubiquitinate RNA polymerase II, dependent on CDK12-mediated Ser2 phosphorylation of the CTD.

Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

This study shows that Piezo1 activation reduces thrombin-induced blebbing in breast cancer cells by increasing cytosolic calcium and modulating ERM protein phosphorylation.

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.