OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
S. Panagiotou, K.-W. Tan, P. M. Nguyen, A. Mueller, A. I. Oqua, A. Tomas, A. Wendt, L. Eliasson, A. Tengholm, M. Solimena, O. Idevall-Hagren
The paper shows OSBP-mediated lipid exchange at ER-secretory granule contacts regulates insulin secretion by controlling cholesterol levels and is influenced by PI(4)P, VAPs, and Sac2.
bioRxiv · Feb 22, 2023Cell Biology